Vol. 29, Nš 4

Cytomorphologic distinctions in accessory reproductive tissues and extra-gonadal testosterone milieu in Carica papaya-treated male rats

Kusemiju, T. O.; Yama, O. E.; Abayomi Olugbenga Okanlawon

KEYWORDS: Carica papaya, testosterone, sprague-dawley rats, accessory organs

ABSTRACT: Introduction: In this study, we reviewed the effects of contraceptive doses of Carica papaya (CP) bark extract on the accessory reproductive organs and peripheral testosterone of rats. Methodology: Sixty mature 6 weeks old male Sprague-Dawley rats randomized into 3 main groups; each further subdivided into 2 groups A and B; 10 rats/subgroup. Group 1: The control fed distilled water (2-4 mL.day–1). Group 2: administered CP (50 mg .mL–1.kg–1.day–1), while Group 3: treated orally at a higher dose of 100 mg .mL–1.kg–1.day–1. At the end of the experimental period, rats were sacrificed. Venous blood obtained, testes and accessory organs harvested for microscopic study. Results: The extracts produced a dose dependent alteration in testes and accessory organs in the rats. Carica papaya significantly decreases peripheral testosterone concentration in both groups. There was a significant reversal in the testosterone concentration of the rats in the group administered CP 50 mg.mL–1.kg–1.day–1 than in those treated with CP (100 mg.mL–1.kg–1.day–1) this suggests injury inflicted in the low dose group were nominal. Conclusion: This study has demonstrated a time dependent reversible alterations in the morphologies of testes and accessory organs treated with contraceptive doses of CP. The reversal outcome suggests that it is safe to exploit its contraceptive use.